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2.5.8 MiRNA upregulation 2.5.8.1 Obefazimod Obefazimod (ABX464) is an oral small-molecule drug that selectively upregulates miR-124 expression to reduce inflammation, developed for moderate to severe UC through a novel anti-inflammatory mechanism targeting pro-inflammatory cytokines like IL-17 and IL-6
That is especially important for active adults and patients trying to improve long-term physical function
High Alt Med Biol
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Side effects were mostly related to rapidly increasing the drug dose at the start of the clinical trial
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